| ncRNA name | Dectin-1 siRNA |
| ncRNA Category | siRNA |
| Disease name | Fusarium solani keratitis |
| Species | Homo sapiens |
| Tissues/Cell_line | human corneal epithelial cells (HCECs) |
| Methods | siRNA transfection, qRT-PCR, immunoblot, flow cytometry |
| Expression pattern | associated |
| Functional description | HCECs express Dectin-1 and TLR2. HCECs demonstrated upregulation of AMPs hBD2 and cathelicidin LL37 following exposure to heat-inactivated F. solani or PAMPs. TLR2 and Dectin-1 knockdown and BAY 61-3606 treatment decreased AMP mRNA upregulation confirming PRR involvement. |
| PubMed ID | 28460048 |
| Year | 2017 |
| Title | Role of Pattern Recognition Receptors in the Modulation of Antimicrobial Peptide Expression in the Corneal Epithelial Innate Response to F. solani. |
| Drug-related ncRNA | NO |
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